Alkaline phosphatase is an important biochemical indicator in biochemical tests, widely distributed in the human liver, bones, intestines, stomach and placenta and other tissues, an enzyme excreted outside the bile via the liver, so generally when the liver, bones and digestive system diseases, often can cause abnormal alkaline phosphatase. Low alkaline phosphatase is generally considered to be due to pathological factors. If one detects low alkaline elements in oneself and the value is close to normal, most of them are not problematic, and when they are not particularly low, they usually need to be rechecked, but if they are significantly lower than normal, they should be seen in a hospital. The main clinical causes of low alkaline phosphatase include the following categories: first, low alkaline phosphatase caused by various causes of anemia, especially in adolescents, children, etc. When anemia is severe, alkaline phosphatase is significantly lower; second, some chronic nephritis, kidney disease, can cause low alkaline phosphatase values; third, when seen in viral infections, sometimes can also cause low alkaline phosphatase Fourth, low alkaline phosphatase can be caused by thyroid insufficiency or reduced thyroid function in children, so extra attention should be paid to low alkaline phosphate in children. Other diseases such as malnutrition, hypoproteinemia, scurvy due to vitamin C deficiency, tumor cachexia, hereditary hypoproteinemia, etc. can also cause low alkaline phosphatase.