Radiotherapy is the best treatment for primary liver cancer that cannot be surgically resected. With the deepening of research and understanding of the biological behavior of liver tumor cells, the comprehensive treatment mode of liver cancer is also evolving, and the original understanding that liver cancer cells are insensitive to radiation while normal liver tissues are sensitive to radiation is completely wrong. On the contrary, the cells of hepatocellular carcinoma have radiotherapy sensitivity equivalent to that of poorly differentiated squamous carcinoma, which is the most sensitive radioactive tumor. At present, the application of new radiotherapy techniques, such as three-dimensional conformal radiotherapy, three-dimensional intensity-modulated radiotherapy, image-guided radiotherapy, 4-DCT radiotherapy, etc., which can kill tumor cells to the maximum extent while preserving normal tissues as much as possible, achieves the relatively non-invasive treatment technique. Therefore, for primary liver cancer that cannot be surgically resected, radiotherapy is the most important treatment modality: 1. For large tumors with necrosis, intrahepatic metastasis or tumors invading the portal vein, hepatic vein, hepatic portal lymph node metastasis, abdominal lymph node metastasis, retroperitoneal lymph node metastasis, radiotherapy should be performed as the main comprehensive treatment. 2. 2. Radiation therapy plays an active role in preventing recurrence after liver cancer resection. 3. For local recurrence of liver cancer after surgery, radical radiotherapy should be performed after TACE if reoperation is not possible. 4. Palliative radiotherapy is the first choice for distant metastasis of liver cancer, such as bone metastasis, distant lymph node metastasis, lung metastasis, brain metastasis, adrenal gland metastasis. Zhang Jiandong, Department of Tumor Radiotherapy, Shandong Qianfoshan Hospital ☆ Liver cancer intervention combined with radiofrequency, which liver cancer treatment can be used? ☆ Liver cancer intervention combined with freezing, which liver cancer treatment can be used? ☆ Which liver cancers can be treated by liver cancer intervention combined with microwave? ☆ Should intervention be done before radiofrequency and cryosurgery, or should radiofrequency and cryosurgery be done before intervention? Can it be done at the same time? ☆ If radiofrequency or cryosurgery has been done before, can intervention be done after a period of time? Who can’t?