Triplet reduction can lead to abnormal coagulation. Many diseases can cause triplet reduction, the most common being aplastic anemia, in which patients may have symptoms of fever, infection, bleeding, and anemia. Usually, they will show easy fatigue, drowsiness, dry skin and thinning hair.
Bone marrow fibrosis also causes a decrease in trilineage and changes in blood cells as the disease worsens.
Triple lineage is also significantly reduced in patients with leukemia, a malignant clonal disease of the bone marrow in which cellular infiltration is the main clinical feature, as evidenced by enlarged lymph nodes, bone pain, and anemia.
Patients with abnormal neurological signs and symptoms are considered to have megaloblastic anemia, and patients will have reduced serum vitamin and folic acid levels. Hemolytic anemia is divided into in situ hemolysis, intravascular hemolysis, and extravascular hemolysis. Patients with red blood cells that are destroyed too rapidly or in excess of the bone marrow’s ability to compensate for them can cause a decrease in the trilineage.
Also, an enlarged spleen, severe infections, severe tuberculosis, sepsis, and epidemic hemorrhagic fever can cause trilineage reduction. Patients need to undergo further testing to clearly diagnose the cause and treat according to the diagnosis.