The causes of osteoporosis are many and complex, such as alcoholism, diabetes, and poor diet, which can cause osteoporosis. However, because people do not know much about the causes of osteoporosis, they cannot prevent it properly. According to the latest research, osteoporosis has a strong relationship with genetic abnormalities. Causes of osteoporosis: 1. Vitamin D receptor gene Vitamin D is one of the important regulators of the bone metabolic pathway, mainly through the regulation of small intestine calcium absorption, osteoblast and osteoclast function, parathyroid hormone production and kidney 25-hydroxy-vitamin D hydroxylation and other processes to maintain the stability of the internal environment of bone and calcium. 2.Estrogen receptor 1 gene Estrogen plays an important role in bone growth and maintenance of bone mass by regulating bone metabolism, peak bone mass acquisition and inhibiting bone loss, and numerous studies have shown that estrogen is essential for maintaining the dynamic balance of bone. 3. Type I and IV collagen genes The type I and IV collagen genes are the most abundant collagen inside the bone. Most studies have focused on the analysis of a polymorphic marker (G” T) located at the Sp1 binding site of intron 1, which has been found to be a functional variant site that can alter the ratio of collagen α1 to α2, leading to fracture. 4, LDL receptor-like protein-5 gene The LDL receptor-like protein-5 gene is a cell membrane surface protein that is a member of the LDL receptor family and is closely related to osteoporosis, and its mechanism may be related to bone mass and osteoblast function. Dietary contraindications for osteoporosis patients: 1, it is advisable to supply sufficient calcium To often eat calcium-rich foods, such as ribs, brittle bones, shrimp, kelp, hairy vegetables, fungus, barrel citrus, walnuts, etc. 2.It is advisable to supply enough protein Milk, eggs, fish, chicken, lean meat, beans and soy products can be used. 3.It is advisable to supply sufficient vitamin D and C because they play an important regulatory role in bone metabolism. You should eat more fresh vegetables, amaranth, potherb mustard, parsley, cabbage, and more fruits.