Eating betel nut causes cancer is not a new thing, and it is not an alarming story. Through long-term tracking survey, researchers found that in Papua New Guinea, nearly 60% of the residents like to chew betel nut, and the country has the second highest incidence of oral cancer in the world. Taiwan, China also has a tradition of betel nut chewing, where there are 27.4 cases of oral cancer per 100,000 male residents. The power of betel nut should not be underestimated. At present, we have a clear understanding of betel nut and oral cancer, but the key problem still lies in the betel nut alkaloids contained in betel nut. Betel nut alkaloids can not only affect our nervous system and put people into a hyperactive state, but also stimulate our oral mucous membrane cells and put them into an abnormal state of life and death. Normally, oral mucosal cells renew themselves and those old cells will fall off and die, but betel nut alkaloids break this life and death balance, prompting the epithelial cells to die in a short period of time. It doesn’t stop there, betel nut alkaloids also fill the extracellular collagen deposits unexpectedly, while betel nut hypocretin, an accomplice of betel nut alkaloids, organizes our organism to remove these excess proteins. The damage brought to us by betel nut does not stop there, as the rough fibers easily pierce the oral mucosa during chewing. This frequent damage also tends to trigger abnormal cell proliferation. Combined with the properties of betel nut alkali mentioned above, the result can be imagined that the cancer is just a qualitative change caused by quantitative change. Therefore, for the sake of your oral health, please do not chew betel nut!