Progesterone can be administered during acute painful kidney stones, especially in women who are pregnant. After using progesterone, the painful symptoms can be relieved by relieving the spasm of the ureter. However, there are some patients with more serious obstruction and treatment with progesterone does not have any effect. And if there is no clear contraindication, progesterone can be used together with analgesic drugs for treatment, such as dulcolax injection or brucine hydrochloride injection for synergistic analgesic treatment, so as to relieve the symptoms of acute renal colic. If intramuscular progesterone does not have any effect, extracorporeal shock wave lithotripsy or inpatient surgery is recommended. Extracorporeal shock wave lithotripsy can break up the stone, which can reduce the obstruction or displace the stone, so that the patient’s pain can be reduced. However, patients with large stones are recommended to be hospitalized directly for surgery to remove the stones from the body through various minimally invasive procedures to completely cure the urinary tract and kidney stones.