Osteoporosis is a systemic bone disease caused by multiple causes of decreased bone density and bone mass, destruction of bone microstructure, increased bone fragility, and susceptibility to fracture. Osteoporosis is divided into primary osteoporosis and secondary osteoporosis. Common causes of osteoporosis include the following: 1. Endocrine disorders. Such as diabetes, hyperthyroidism, Cushing’s syndrome, hypogonadism, pituitary lactinoma, hypopituitarism and other diseases. In the middle and elderly people, the reduction of sex hormone secretion is one of the important causes of osteoporosis. 2.Lifestyle factors. Bad lifestyle, such as frequent lack of sunlight, staying up late, lack of exercise, will affect the metabolism of bones, leading to osteoporosis. 3, drug factors. The use of certain drugs for too long, including adrenal glucocorticoids, anti-cancer drugs, anti-epileptic drugs, etc. can also cause osteoporosis. 4, digestion and absorption factors. Such as chronic gastritis, post-gastrectomy, chronic pancreatic disease, chronic liver disorders, malnutrition and other patients often accompanied by osteoporosis. 5, genetic factors. Osteoporosis has some heredity. In summary, the common causes of osteoporosis, osteoporosis pathogenesis and treatment factors are very complex, the specific pathogenesis is still under continuous in-depth research.