Gout is a disease caused by disorders of purine metabolism and impaired uric acid excretion, characterized by hyperuricemia and the resulting recurrent episodes of gouty acute arthritis, gouty stone deposits, gouty chronic arthritis, joint deformities, chronic interstitial nephritis, and uric acid kidney stones. It is evident that gout can cause serious harm to humans. So how does gout occur? First, let’s get to know purine, an important base in living organisms whose metabolite in the body is uric acid. There are two main sources of purine in the body, one is from purine-containing foods, which accounts for about 20% of uric acid in the body, and the other is from the breakdown of amino acids in the body, which accounts for about 80% of uric acid in the body. When the purine in the body increases, more uric acid will be produced, and the kidneys cannot excrete uric acid out of the body in time, it can cause hyperuricemia. When the concentration of uric acid in the blood is greater than 6.39mg/ml (380Umol/L), supersaturation will be formed, and uric acid will precipitate out and form crystals in the joints, cartilage, synovial membrane and kidney tissue, causing pain and dysfunction, leading to gout attacks. When uric acid is excreted in excess, stones are easily formed in the urinary system. The concentration of uric acid in the serum depends on the balance between the rate of production and excretion of uric acid. The accumulation of uric acid in the body can be seen in the following situations: 1) increased exogenous absorption, both from the intake of purine-rich foods; 2) increased endogenous biosynthesis, mainly due to enzymatic defects in purine metabolism, resulting in accelerated nucleic acid decomposition and increased purine oxidation to produce uric acid; 3) reduced excretion: reduced excretion from the kidneys via urine and reduced intestinal bacterial decomposition after secretion from the bile and stomach; 4) reduced internal metabolism , both endogenous destruction of uric acid is reduced; the above factors together lead to an increase in blood uric acid concentration. It can be seen that blood uric acid concentration plays an important role in the occurrence and development of gout. Once you have gout, you should actively treat it: firstly, terminate the acute arthritis attack as soon as possible; secondly, prevent the recurrence of arthritis to correct hyperuricemia and prevent the formation of kidney stones. The central aspect of its prevention and treatment is the prevention of elevated blood uric acid levels. Our goal is to control blood uric acid below 6.0 mg/ml, and then we can effectively prevent gout attacks and complications. One of the important measures to control elevated blood uric acid levels is a proper diet, especially a low purine diet. Food is divided into three categories according to the purine content: the first category is food with high purine content: both 100-1000mg of purine per 100g of food, such as animal offal: liver, kidney, pancreas, heart, brain, etc., meat pies, broth; fish and shrimp: such as carp, fish eggs, small shrimp, snake; goose, chicken, yeast (for brewing, baking bread). The second category is food with medium purine content: 90-100mg of purine per 100g of food; meat: pork, beef and lamb; vegetables: soybeans and soy products, spinach, peas, mushrooms, lentils, asparagus, etc. The third category is foods containing trace amounts of purines: milk, eggs, refined white flour, rice, cabbage, radish, celery, etc. In the acute stage of gout, foods with high purine content should be strictly limited, and foods with trace purine content should be chosen, with milk and eggs as the main high-quality protein in the diet, refined white flour and rice to provide calories, and vegetables to provide dietary fiber; while in the remission stage of gout, a normal balanced diet should be maintained, with ideal body weight and normal blood uric acid level maintained, and protein limited to In the remission period, we should maintain a normal balanced diet, maintain the ideal body weight and normal blood uric acid level, limit protein to 1g/kg body weight, avoid the first type of food containing high purine, and choose the second type of food containing medium purine in a limited way, and choose the food containing medium purine for 2 days a week; choose the food containing a small amount of purine for 5 days. Avoid excessive intake of fatty tissue to avoid obesity. In addition to mastering the above dietary principles, special attention should be paid to the following points: 1. Pay attention to vitamin supplementation, especially vitamin C, because vitamin C can promote the dissolution of uric acid salts deposited in tissues. 2, alkaline food can make the urine alkaline, conducive to the discharge of uric acid, can eat more green vegetables (cabbage, radish, celery, etc.). 3, eat fine grains not coarse grains: coarse grains in purine content is significantly higher than fine grains, so gout patients should eat less or do not eat coarse grains. 4, vegetable oil has less purine content than animal oil, so it is appropriate to choose vegetable oil. 5.Mineral water, soda, Sprite and cola contain almost no purines and can be used; tea contains a small amount of purines and should be consumed in limited quantities. Coffee contains a small amount of purine and a large amount of caffeine, so it is better not to use it. 6. 70% of uric acid in the body is excreted by the kidneys, so you should drink more water and keep the daily urine volume above 3000ml, which is conducive to the excretion of uric acid. 7, alcoholism is one of the causes of gout, alcohol can inhibit the excretion of uric acid by the kidneys, which can directly accelerate the synthesis of purine in the body, especially beer, which produces a large amount of purine in the fermentation process, too many references will cause a significant increase in blood uric acid. A low purine diet is one of the main measures to prevent and control gout attacks, but a simple low purine diet cannot completely prevent and control gout attacks, and must be combined with medication and other treatments under the guidance of a doctor to more effectively prevent and control gout attacks.