The duration of crystal lysis pain after taking febuxostat varies from patient to patient, generally within 2 weeks, or up to 1 month in some patients. Gout attacks are caused by the rapid dissolution of uric acid crystals in some gout patients after taking febuxostat, resulting in fluctuations in blood uric acid levels in the body. However, the duration of crystal lysis pain varies from patient to patient, generally within 2 weeks, or up to 1 month in some patients, or without crystal lysis pain in some patients. The lysis pain can be prevented by not taking febuxostat during the acute phase of gout attack when the joint swelling and pain are obvious, but starting to take febuxostat after the joint swelling and pain have disappeared; or taking febuxostat together with non-steroidal anti-inflammatory painkillers at the early stage of taking febuxostat. In addition, gout patients taking febuxostat should continue to strictly control their diet, maintain regular work and rest, and exercise appropriately.