Chemotherapy regimen for stage IVC undifferentiated thyroid cancer

Protocol

Drug/Dose

Frequency

Paclitaxel/carboplatin

Paclitaxel 60-100 mg/m2, carboplatin AUC 2 mg/m2 IV

weekly

paclitaxel/carboplatin

Paclitaxel 135-175 mg/m2, carboplatin AUC 5-6 mg/m2
IV

every 3 to 4 weeks

Docetaxel/Doxorubicin

Docetaxel 60 mg/m2 IV, doxorubicin 60 mg/m2 IV
(subject to polyethylene glycolated filgrastim support)

every 3 to 4 weeks

Docetaxel/Doxorubicin

Docetaxel 20 mg/m2 IV, doxorubicin 20 mg/m2 IV

weekly

paclitaxel

60-90 mg/m2 IV

weekly

Paclitaxel

135 to 200 mg/m2 IV

every 3 to 4 weeks

Doxorubicin

60 to 75 mg/m2 IV

every 3 weeks

Doxorubicin

20 mg/m2 IV

Weekly

Note: AUC, area under the concentration-time curve; IV, intravenous drip