Intestinal epithelial metaplasia cannot be cured and cannot be reversed once it occurs, but it can be treated medically to relieve the discomfort caused by intestinal epithelial metaplasia and to prevent further aggravation of the disease. Intestinal epithelial metaplasia, referred to as intestinal metaplasia, refers to the replacement of gastric mucosal epithelial cells by intestinal-type epithelial cells, that is, gastric mucosal cells become mucosal cells similar to the epithelium of the small intestine or colon. Intestinal metaplasia occurs in patients with chronic atrophic gastritis. Due to the decrease of gastric juice secretion caused by excessive atrophy of gastric mucosa, the intestinal mucosal epithelium will grow compensatively to secrete mucus, which is called intestinal epithelial metaplasia and is an important link in the evolution of chronic atrophic gastritis to gastric cancer. Therefore, if intestinal epithelial hyperplasia appears in the local mucosa, it should be noted that there may be a risk of malignant transformation. Usually, intestinal epithelial hyperplasia can be treated by medications to relieve abdominal discomfort, belching, heartburn, diarrhea and other symptoms. Common medications include aluminum thioglycollate, tioprednisone, montelukast, ranitidine, metoclopramide, domperidone and other drugs, which can eliminate gastric mucosal damage factors and improve mucosal barrier defense function, thus relieving symptoms. Patients should use the medication correctly according to the doctor’s instruction to avoid causing adverse reactions.