If a patient develops angina in the middle of the night while sleeping, the first consideration is cardiogenic diseases, such as acute coronary syndrome, coronary artery disease, arrhythmia, heart failure, and also for factors such as acute myocarditis, pericarditis, infective endocarditis, and even aortic coarctation. For diseases of the respiratory system, such as acute bronchitis, bronchiectasis, various factors leading to pneumothorax, pleural effusion, and pulmonary infection pleurisy, this can also manifest. For diseases of the digestive system, such as biliary reflux gastritis, gastroduodenal ulcer, and reflux esophagitis, there can also be pain in the precordial region when sleeping in the middle of the night. Finally, for patients with vegetative nerve disorders, if they develop cardiac neurosis, they may also have angina attacks in the middle of the night.