Traditional treatment for condyloma acuminatum (CA) includes two main categories of medication and physical therapy. Traditional medication includes trichloroacetic acid, 5-fluorouracil, and onychotoxin; physical therapy mainly refers to laser, high-frequency electric knife, freezing, microwave, and surgical excision. These methods can remove warts faster, but warts recurrence rate is high, generally in the treatment of 3 to 6 months after the most common recurrence, the median recurrence rate of 30% to 40%, is one of the headache for many STD doctors. 1, there are HPV subclinical infection and latent infection: the so-called subclinical infection refers to the HPV virus has been infected, but has not grown warts, need to use a magnifying glass, colposcopy, urethroscopy or 3% to 5% of glacial acetic acid external coating to observe the lesion area. Subclinical infections are easily missed because of the lack of morphological changes visible to the naked eye. Subclinical infection of condyloma acuminatum is an intermediate process from HPV infection to the development of CA. It is believed that the duration of latent infection is related to the immune function of the infected cells and the virulence of the infected cells, and can last for several years. . In addition, the number of Langerhans cells within the CA lesions of relapsed patients is reduced, making the presentation of HPV antigens within the epidermal cells weakened, making it difficult for the body to generate a strong HPV-specific immune response, which also becomes the cause of some recurrence of condyloma acuminata. 3, the role of estrogen: estrogen is one of the important cofactors of HPV pathogenesis, many STD scholars have this experience, pregnant women infected with HPV, the rapid development of the lesion, the size of the warts increased significantly, the number of difficult to treat, the treatment of recurrence rate is higher, after giving birth to the acromegaly can be significantly subside. The estrogen receptor is also related to the occurrence of HPV infection and CA. 4, the treatment is not standard: including topical drugs and physical therapy two aspects. 5, sexual partners are not treated: become an important source of infection and cause recurrence of important reasons. 6, other reasons: including HPV genetic susceptibility, underwear of their own infection, circumcision, co-infection with other sexually transmitted diseases, while suffering from other diseases that lead to lower immunity (such as diabetes, autoimmune diseases) and repeated infection with HPV virus.