The most common symptom of osteosarcoma is a localized soft tissue mass in the bone, accompanied by varying degrees of pain. Osteosarcoma occurs in adolescents, and because of the high degree of malignancy, it is necessary to seek medical attention when some symptoms appear in order to avoid delaying the disease. 1. Progressive aggravated pain: unexplained bone pain in the limbs and bone ends, with deeper pain, from mild pain to more severe pain, progressive aggravated pain has a certain clinical specificity; 2. The pain can be felt when the patient does not exercise, and the pain is more obvious at night; 3. Skin pain: In addition to bone pain, there will be localized swelling of the skin, elevated skin temperature, and angry veins, etc. Skin pain is an advanced manifestation of bone pain; 4. Joint flexion: Some patients subconsciously flex their joints to relieve pain, and prolonged flexion will lead to Osteolytic osteosarcoma occurs at the junction of bone and soft tissue, and patients will have restricted activity and pathological fracture; 6. Fever: As the disease progresses, unexplained fever, weight loss and even distant metastasis to the lungs may occur, leading to multi-organ failure. Once the early symptoms of osteosarcoma appear, treatment can be carried out by drugs and surgery under the guidance of doctors. Surgical treatment is based on the principle of extensive local excision while preserving the limbs, and the prognosis usually needs to be determined based on factors such as the stage of cancerous tissues and whether lymphatic tissues are involved.