Hepatitis B major triple-positive, that is, positive for hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B core antibody (anti-HBC), reflects the immune status of the virus when it is present in the body, and patients with hepatitis B major triple-positive have strong viral replication and are highly infectious. Hepatitis B surface antigen positive: Hepatitis B surface antigen can be positive after 2 weeks of hepatitis B virus (HBV) infection, reflecting presenting hepatitis B virus infection, but negative cannot exclude hepatitis B virus infection. Hepatitis B surface antigen can persist for years, even for life, in asymptomatic carriers and chronic patients. Hepatitis B surface antigen itself is only antigenic and not infectious. Hepatitis B e antigen positive: Hepatitis B e antigen has a good correlation with hepatitis B virus DNA. The presence of hepatitis B e antigen indicates active viral replication and strong infectiousness, indicating that the patient is in a high infection low response period. Hepatitis B core antibody positive: Hepatitis B core antibody can be detected in almost all people infected with hepatitis B virus. Hepatitis B core antibody IgM is an antibody that appears earlier after HBV infection and is positive to indicate acute phase or acute attack of chronic hepatitis. Therefore, hepatitis B major triple-positive, suggesting that the virus replication in the body is more active, more contagious, can be transmitted through mother-to-child transmission, blood, body fluid transmission, sexual transmission of the way. Therefore, patients with hepatitis B major triple-positive need early medical treatment, while those who are not infected with hepatitis B virus, to prevent infection advocate active or passive immunization, strengthen blood management, develop good personal hygiene habits, cleanliness, etc.