In recent years, hepatic artery chemoembolization has been recognized as the treatment of choice for mid- to late-stage hepatocellular carcinoma, turning the “incurable disease” into a partially curable one. However, the effect of chemoembolization depends on whether the chemoembolizing agent is “completely filled” in the tumor tissue. As we all know, tumor patients have low immune function, 80% of liver cancer patients have cirrhosis background, especially for massive liver cancer, the toxic side effects of prolonged and repeated chemoembolization (especially chemotherapy drugs) may make patients “worse”, which is its shortcoming and deficiency. Nowadays, for the treatment of middle and late stage liver cancer that cannot be surgically resected, the trend is to optimize the combination, joint application and sequential treatment of multidisciplinary and multi-technology, which is the result of the rapid development, crossover and integration of modern medicine and high technology, which makes the high efficiency and low toxicity of minimally invasive tumor treatment possible. The specific methods of arterial embolization combined with ultra-low temperature freezing in the treatment of middle and advanced liver cancer: The combination of two high technologies, firstly, hepatic artery embolization (HAE) is used to embolize the tumor vascular bed with high selection and target. Primary hepatocellular carcinoma is mostly rich in tumor neovascularization, thus the greedy tumor cells can keep growing. Hepatic artery embolization can greatly reduce or block tumor blood supply and put tumor cells in ischemic “starvation” or even “shock” state; inhibit the “hot pool effect” of fluid nature of tumor vessels, which is conducive to greatly improve the efficiency of freezing. “It is beneficial to improve the freezing efficiency significantly. Secondly, ultra-low temperature freezing technique is used after 3-4 weeks. The specific method is to place the freezer into the preset target tumor area by percutaneous puncture under CT or ultrasound positioning and guidance, and input argon gas. Within minutes, the ultra-low temperature freezing will reach -120℃~145℃ for 15~20 minutes, repeatedly freezing and thawing twice to “freeze” the tumor cells to a large extent and minimize the damage to normal liver tissue. The treatment features are: two kinds of high and new technologies have complementary advantages, the synergistic and superimposed effects of treatment, making the tumor suffer from “starvation and cold”; causing extensive necrosis of tumor in a short period of time, reducing the residual of living tumor tissue; shortening the treatment cycle, relatively reducing the cost of treatment; reducing the number of chemotherapy drugs used, reducing their toxic side effects on liver function, and protecting cellular immune function. and protect the cellular immune function. More importantly, by rapidly reducing the tumor load in a short period of time, the release of tumor factors is reduced, and the cellular immune function of patients is significantly improved, which significantly improves the quality of life of patients. Thus, this new highly effective and less toxic technological approach shows a new concept of “green” treatment for mid- to late-stage liver cancer.