There is no direct correlation between soreness in the cheeks and the development of lymphoma, and only in conjunction with a pathologic diagnosis may it be possible to prove the presence of lymphoma in a patient. Soreness in the cheeks may be due to enlargement of the parotid gland or fatigue of the chewing muscles. When the opening of the parotid duct becomes narrowed due to infection or trauma, the fluid secreted by the parotid gland cannot be discharged to the oral cavity through the parotid duct, and accumulates in the gland, causing edema, which results in the sensation of soreness and swelling. And one of the early symptoms of lymphoma is neck enlargement, so when both cheeks are sore, you should observe whether both cheeks and neck are enlarged. If the texture of lymph nodes on both sides is very hard and there is a possibility of continuous enlargement, and ultrasound finds that parotid or neck lymph nodes are obviously enlarged, ultrasound-guided puncture should be carried out, and if the biopsy reveals the presence of lymphoma cells, there is a possibility of the existence of lymphoma. Lymphoma is a systemic disease, if you have symptoms of soreness in cheeks, you need to refer to your body for other symptoms and discomforts, and when in doubt, you can undergo ultrasound examination first to find out the problem before proceeding to the next step of treatment.