Whether lymphoma, also known as lymphoma, is dangerous or not in late stage depends on different causes and cannot be generalized. The dangerous state of patients in advanced lymphoma edema caused by different causes is also different.1. Hypoalbuminemia: With the consumption of tumor on the body in advanced lymphoma, the overall feeding or liver function of patients will be impaired, and the synthesis of albumin will be reduced, which leads to hypoalbuminemia. Hypoalbuminemia mainly manifests as peripheral edema and increased leakage of intravascular fluid, causing lower limb edema or generalized edema, in addition to pleural effusion and peritoneal effusion. Supplementary nutrition should be given to correct the state of lowered albumin. If the treatment is effective, the patient’s symptoms will be gradually reduced, and if the patient can tolerate the systemic anti-tumor treatment subsequently, his survival will be further prolonged, so it is not a serious dangerous state; 2. Lower limb venous thrombosis: some patients with advanced lymphoma have lower limb edema, which may be due to the combined lower limb venous thrombosis, manifested as localized swelling and pain of blood vessels or lower limbs. The diagnosis can be confirmed by vascular ultrasound examination, and patients can choose warfarin sodium, rivaroxaban and other drugs for anticoagulation treatment, if the treatment is effective, it is not a dangerous state; 3. Tumor spread: lymphoma tumor in advanced stage is more extensive or too large to cause relevant compression, resulting in local edema, and patients may be accompanied by hemorrhage, fever, anemia and decreased immune system function, which may seriously affect patients’ This is a more dangerous situation. Patients are advised to lie down and elevate the affected limbs to relieve edema, and go to hospital for chemotherapy at the same time. In addition, patients with advanced lymphoma should be treated symptomatically to prolong their life and improve their quality of life. If patients have good effect of radiotherapy and chemotherapy, they can choose surgery to remove tumor cells in their body to gain more time for survival.