Gout is a disease with a genetic predisposition, which means that it has a certain chance of being inherited, but it is by no means 100% hereditary, and whether or not it develops depends on a number of factors, such as personal constitution, diet and environment. Therefore, although some people have relatives with gout, it does not necessarily mean that they will develop gout. Gout can be divided into two categories: primary gout and secondary gout, of which primary gout is associated with genetic factors, i.e., it has a certain degree of family heredity. Patients with primary gout are born with a defect in purine metabolizing enzymes and have an impairment in purine metabolism, resulting in elevated blood uric acid, which can easily trigger gout. It has also been shown that the incidence of gout is higher in first-degree relatives of gout patients than in those without a family history of gout. In addition, the younger the age of onset, the higher the blood uric acid level, the more complicated the gout condition, and the less effective the treatment, the more gout patients have a family history of gout and a more pronounced genetic predisposition. Therefore, although gout is not a 100% genetic disease, it has a clear genetic predisposition, and the incidence of gout is higher in people with a family history of gout. These people should pay more attention in their daily life, avoid eating too much high purine food and drinking alcohol, exercise properly, control their weight, and consult a doctor as soon as the symptoms of elevated blood uric acid and suspected gout appear.