Epidemiological data suggest that young pregnant women are susceptible to gallbladder stones. The main reason for this is the increase in serum endogenous estrogen and progesterone concentrations during pregnancy, which leads to increased uptake and catabolism of plasma LDL by the liver, resulting in increased cholesterol excretion into the bile duct. As cholesterol accumulation in the biliary tract increases, bile cholesterol saturation and bile stone formation index increase, eventually leading to the formation of gallbladder stones. In addition, in the middle and late stages of pregnancy, the rate and proportion of gallbladder emptying decreases due to the increase in fasting gallbladder volume and residual gallbladder volume after contraction, which is more likely to contribute to the formation of gallbladder stones.