When there is acute decline in renal function, central nervous system damage, massive pericardial effusion, thrombocytopenia, hemolytic anemia and other acute and critical conditions, methylprednisolone shock therapy should be used after excluding serious infections:. The method is 1 gram per day for 3 days, followed by 50 mg of prednisone per day orally, which can be repeated after 2 to 3 weeks depending on the condition. However, it has also been repeated after 1 week in critically ill patients to gain time and save lives. During the period of methylprednisolone shock, the condition should be closely observed to cuantify and prevent complications such as infection and bleeding, as well as central nervous symptoms caused by high-dose application of glucocorticoids, such as disordered thinking, loss of emotional control, insomnia, and excessive dreaming.