Many patients with osteoporosis often have no obvious symptoms in the early stages of the disease and are often found to have osteoporosis only after the fracture has occurred, when it is too late, by X-ray or bone density. Therefore, assessing individuals for osteoporosis risk can help identify osteoporotic patients early and help take appropriate control measures as soon as possible. International Osteoporosis Foundation (IOF) Osteoporosis Risk One-Minute Test Questions: 1. Have you ever injured your bones due to a minor bump or fall? 2.Have your parents ever had a hip fracture from a minor collision or fall? 3.Do you often take hormonal drugs such as cortisone and prednisone for more than 3 months in a row? 4.Have you lost height (more than 3 cm) compared to your youth? 5.Do you often drink a lot of alcohol? 6.Do you smoke more than 20 cigarettes a day? 7.Do you often suffer from diarrhea? (caused by gastrointestinal diseases or enteritis) 8.Ms. answer: did you become menopausal before the age of 45? 9.Women: Have you ever had no menstruation for more than 12 months in a row (except during pregnancy)? 10. Men: Do you suffer from impotence or lack of sexual desire? A “yes” answer to one of these questions is considered positive. Bone mineral density (BMD) measurements (two-photon bone densitometry) are used as the best quantitative indicator for diagnosing osteoporosis, predicting the risk of osteoporotic fractures, monitoring the natural course of the disease, and evaluating the efficacy of pharmacological interventions. Bone density is the amount of bone per unit volume (bulk density) or per unit area (area density). For those with risk factors for osteoporosis, routine blood tests, calcium, phosphorus, alkaline phosphatase, lateral radiographs of the thoracic and lumbar spine and discretionary items, including blood sedimentation, gonadotropins, 25OHD, 1.25(OH)2D, parathyroid hormone, urinary calcium and phosphorus, thyroid function, cortisol, blood gas analysis, blood and urine light chain, tumor markers, and even radionuclide bone scan, bone marrow aspiration or bone biopsy. If there are abnormal laboratory tests, further exclude other endocrine metabolic diseases; if the results are normal, but there are fractures, do bone density and treatment; if the results are normal without fractures, do bone density test, TQ-2.5 as a confirmed diagnosis, be treated.