Hemangioma is a vascular malformation or tumor caused by abnormal development of vascular tissues, mostly appearing 1 to 3 months after birth, mostly in facial skin, subcutaneous tissues and oral mucosa, a few occur in visceral tissues such as liver and kidney, with the risk of breakage and bleeding, infection and pigment scarring, etc. It needs active treatment, and needs to be differentiated from the following 3 diseases in clinical work: 1. Differentiation between hemangioma and hemangioblastoma Diagnosis Angiosarcoma mostly refers to sharp painful swellings occurring in and around the nail bed of fingers and toes, and the pain will be significantly aggravated when stimulated by cold. If the tumor is located under the nail, it can be seen that the nail bed of fingers and toes is partially elevated, and the surface is light red, purple or slightly dark, and the pressure will produce pain, so the patients mostly do not allow touching, and there will be painful expression when touching. 2.Differential diagnosis of angiosarcoma and hemangiosarcoma Angiosarcoma is rare, the tumor is nodular, painless, purple-red in color, easy to bleed and rupture in superficial cases, many disorganized tumor blood vessels are seen microscopically, tumor cells proliferate in the basal cell membrane, which can adhere to the inner wall of blood vessels and form nodules protruding from the lumen, tumor cells are spindle-shaped, or polygonal in poorly differentiated cells, large nuclei, may be multinucleated, cytoplasm The nuclei are large and may be multinucleated, and the cytoplasm is darkly stained, with giant cells. Immunohistochemistry is important for definite diagnosis and differential diagnosis, and endothelial markers such as factor VIII-related antigen, CD31 and CD34 can be selected. 3.Differential diagnosis of hemangioma and hemorrhagic nodule In general, hemangioma has typical shape and features of shrinking or lightening color when acupressure is applied. If necessary, needle aspiration can be used, and fresh blood can be drawn from the hemangioma, while old blood is drawn from the hemorrhagic nodule and can be mixed with other components.