Multiple myeloma is a malignant tumor originating from the hematological system and is often overlooked by clinicians in other departments. In less than a year, our department has treated more than ten patients with misdiagnosed new-onset multiple myeloma, most of whom have now had their disease controlled and their clinical symptoms have improved significantly. Multiple myeloma is one of the medical disorders that are more likely to be misdiagnosed. In clinical practice, it is often misdiagnosed as “osteoporosis”, “metastatic bone cancer”, “lumbar spine tuberculosis”, “kidney disease”, “recurrent pneumonia” and “recurrent pneumonia”. It is often misdiagnosed as “osteoporosis”, “metastatic cancer of bone”, “tuberculosis of lumbar spine”, “nephropathy”, “recurrent pneumonia”, “urinary tract infection”, etc. The diagnosis should be differentiated from reactive plasmacytosis, monoclonal immunoglobulinemia of undetermined significance, primary macroglobulinemia, primary systemic amyloidosis, monoclonal immunoglobulinemia with non-plasmacytosis, metastatic carcinoma of bone, tumor of bone, primary nephropathy, hyperparathyroidism and other diseases. In China, the clinical misdiagnosis rate of 2547 cases of multiple myeloma has been reported as high as 69%. The patient, Jin, was treated for abnormal renal function in an outside hospital before he was seen in our hospital. Wang presented with bilateral chest pain without obvious cause six months ago at an external hospital for X-ray and CT examination suggesting T6 and L2 vertebral compression fractures, and was given blood circulation, analgesia and calcium treatment with no improvement in symptoms. Li unit physical examination found high blood creatinine, and then re-examined twice to check the blood creatinine value are gradually increased, and a number of tests after still not clearly diagnosed. Duan only complained of bilateral crotch pain and discomfort, magnetic resonance examination suggested abnormal signal of iliac bone, which was not diagnosed in Zhengzhou and other large hospitals, and was misdiagnosed as rheumatic polymyalgia when he came to our department. …… and so on. All of the above patients have been consulted by multiple departments and hospitals, and have had a difficult experience in seeking medical treatment, and patients have suffered from pain for months or even years without clear diagnosis and treatment. With his excellent medical skills and rich clinical experience, he has been able to solve the pain of patients. Multiple myeloma is a common disease in hematology, commonly manifested as bone pain, anemia, renal insufficiency, infection and hypercalcemia.