The ovaries are the female gonads whose main function is to produce eggs and ovulate and to secrete female hormones. Ovarian hypofunction, also known as premature ovarian failure, is usually caused by loss of follicular function in the ovaries or by medically induced damage, but can also be idiopathic and is mainly characterized by decreased estrogen levels or increased gonadotropin levels. Diminished ovarian reserve function, early detection of ovarian insufficiency, and premature ovarian failure represent three different stages of gradual decline in ovarian function. Treatment is mainly related to estrogen supplementation, or for women with fertility requirements, natural estrogen and progesterone supplementation. These patients need long-term medication to establish normal artificial cycles and continue treatment until the average natural menopausal age, after which they can refer to the post-menopausal hormone supplementation regimen for continued treatment. In conclusion, ovarian hypofunction is irreversible and only external hormone supplementation can be used to maintain normal hormone levels for treatment purposes, while maintaining a happy and cheerful mood is also beneficial to the treatment of premature ovarian failure.