The classic symptoms of kidney cancer that have been used for decades in the past include: (1) hematuria, or blood in the urine; (2) abdominal pain, pain in the area of the kidney, that is, at the rib cage; and (3) palpable abdominal mass, meaning that the patient or the doctor can touch the mass through the skin. Other symptoms (systemic manifestations): weight loss, fever, night sweats, loss of appetite, weakness and other common symptoms of malignant tumors. As well as symptoms directly caused by cancer metastasis, such as chronic cough caused by lung metastasis, bone pain caused by bone metastasis, jaundice caused by liver metastasis, etc. Paraneoplastic syndrome: literally means tumor-related syndrome, mainly due to the protein produced and secreted by kidney cancer into the blood, resulting in one or more of the following symptoms: (1) Hypercalcemia, or a rise in calcium ions in the blood. This may lead to weakness, decreased body mass, slowed reactions and altered mental status. (2) Erythrocytosis, a rise in red blood cell count (as opposed to anemia), which in severe cases can lead to blood clotting or embolism. (3) Diabetes mellitus, which is blood sugar above the normal range, with an incidence of 10-20%. (4) Hypertension, which may be related to hormones secreted by kidney cancer (e.g. renin), causing blood pressure to rise. (5) Impaired liver function without liver metastasis, also known as Stauffer’s syndrome, which may occur in 10-15% of patients. All the above signs and symptoms mostly suggest that kidney cancer has developed more severely and the treatment is relatively more complicated.