Case: Patient Xu XX, male, 51 years old, was diagnosed as left frontotemporal glioma grade II in Southern Hospital 3 years ago due to transient anhedonia, and underwent surgery. In the past 5 months, he developed weakness of the right limb, slow movement, and gradual dullness and lack of fluency in speech. In recent January, the symptoms were significantly aggravated, the weakness of the right limb was obvious, the speech was poor, only simple words could be said, no convulsions, no obvious headache, dizziness, sometimes there was poor swallowing, no choking cough, in Peking University Shenzhen Hospital, the cranial MRI examination showed that the tumor recurrence, now come to our hospital, admitted for further treatment. Physical examination: clear consciousness, slightly unresponsive, partial motor aphasia, no tremor in both eyes, slightly limited gaze to the right, tongue extension in the center, symmetrical nasolabial sulcus, the rest of the cranial nerve examination did not show any abnormalities. The rest of the cranial nerve examination was not abnormal. The neck was soft and non-resistant. The muscle strength of the right upper limb was V0, the lower limb was V0-, the muscle tension of the right limb was slightly high, the tendon reflex was slightly hyperactive, the muscle strength and muscle tone of the left limb were normal, and the sensation was normal. Physiological reflexes were present, pathological reflexes were not elicited. 09-4-30 External cranial MRI: left frontal lobe cystic occupancy, about 6.5cm*6.5cm*5cm in size, mixed signal lesion seen at the top of left frontal, about 3cm*3.5cm*5cm in size, surrounding edema seen, left ventricle compressed, midline shifted to the right. Diagnosis: 1. postoperative recurrence of left frontal glioma, 2. type II diabetes mellitus. After admission, the three major routine and biochemical tests did not show any significant abnormality. On 2009-05-08, a left frontal cyst puncture and fluid reservoir implantation was performed under general anesthesia, after which the patient’s speech and movement improved, but the symptoms gradually worsened again, and the symptoms were relieved after puncture and fluid extraction. After discussion, on 2009-05-27, the patient underwent craniotomy of left frontotemporal tumor + decompression of temporal muscle under general anesthesia, and was treated with symptomatic treatment such as dehydration, anti-infection, blood sugar control and immune enhancement, and the patient gradually recovered. Lumbar puncture showed that the intracranial pressure was basically normal. The patient is now discharged from the hospital. Discharge diagnosis: 1. postoperative recurrence of left frontoparietal glioma, 2. type II diabetes mellitus. Discharge status: good general condition, no fever, no headache and dizziness, no nausea and vomiting, no convulsions. Good mental appetite, normal urination and defecation. Physical examination: clear consciousness, partial motor aphasia, right upper limb muscle strength V0, slightly poor right hand fine motor, lower limb V0, physiological reflexes present, pathological reflexes not elicited. Medical tips: 1. Malignant glioma is an intracranial tumor with the highest morbidity, high malignancy and high mortality; 2. Malignant glioma needs comprehensive treatment, i.e. surgery + radiotherapy + chemotherapy + biotherapy + Chinese herbal medicine; 3. After regular comprehensive treatment, the five-year survival rate of glioma is greatly improved; 4. Patients with glioma should be treated actively and face it bravely. They will definitely be able to overcome the devil.