Pregnancy is always full of beauty and anticipation, and the 280-day process highlights the greatness of the pregnant mother. The joy of watching her baby grow day by day is beyond words. However, pregnancy is also a period of rapid psychological and physical changes for women, and while these “new normal” conditions are necessary for the growth of the baby, they also imply the risk of disease. This includes appendicitis in pregnancy. Appendicitis is a common disease, and many old white people say that appendicitis is like rice – cut it and you’ll be fine. But when appendicitis is involved in pregnancy, things are not so simple. Acute appendicitis is the most common surgical complication during pregnancy, with an incidence of 1-2 per 1,000 pregnant women, mostly in the middle and late stages of pregnancy. Appendicitis is a threat to the safety of pregnancy and is definitely a “dangerous gift” for the fetus. Can pregnancy trigger appendicitis? The answer is no! The cause of appendicitis is obstruction of the lumen, which can be triggered by dietary habits, genetic factors and gastrointestinal dysfunction. The enlargement of the uterus during pregnancy squeezes the intestines and affects intestinal motility, etc., creating certain conditions for the development of appendicitis, but there is no such thing as pregnancy causing appendicitis. What are the threats of appendicitis to pregnant women? In addition to the “normal-like” threat to pregnant women, appendicitis can lead to fetal growth retardation, low birth weight and congenital malformations, increasing the probability of preterm delivery and miscarriage. If appendicitis worsens and perforation occurs, causing peritonitis, the life of the pregnant woman will be seriously threatened. Is appendicitis due to right lower abdominal pain in pregnant women? Diagnosis of combined appendicitis in pregnancy is difficult because of the many causes of right lower abdominal pain during pregnancy. The early signs of appendicitis are masked by the nausea and vomiting that are characteristic of pregnancy, the enlarged uterus squeezes out the appendix, creating an “atypical” presentation, and the characteristic increase in white blood cells and C-reactive protein is also common during pregnancy. This requires more reliance on ancillary tests to assist in the diagnosis. Ultrasound is the safest diagnostic tool for appendicitis during pregnancy; CT is more effective than ultrasound, but its radiation is contraindicated during pregnancy. Magnetic resonance imaging (MRI) has a high diagnostic yield and is an ideal screening tool during pregnancy. MRI is based on hydrogen proton resonance imaging with a magnetic field and does not involve radiation. How is appendicitis in pregnancy treated? The American Society for Minimally Invasive Endoscopic Surgery recommends laparoscopic surgery as a safe procedure for pregnant women at all stages of pregnancy. The traditional open appendectomy can be performed in conjunction with a cesarean section, facilitating collaboration between general surgeons and obstetricians and gynecologists, and is particularly suitable for appendicitis in late pregnancy and in the prodromal period. However, due to the unique nature of pregnant women and public “concerns” about surgery, there is still a large “market demand” for conservative treatment. However, in the event of appendiceal perforation and spread of inflammation during conservative treatment, a series of adverse outcomes such as miscarriage can easily result. For such a “dangerous gift”, both the fetal baby and the pregnant mother can not afford to use it. Raising awareness of the disease in pregnant women, timely detection, timely diagnosis and timely surgery are the best means to resolve the danger.