Thyroid nodules are a common disease of the thyroid gland. If an ultrasound examination indicates a thyroid nodule with calcification, it indicates that the thyroid nodule may be cancerous. Clinically, thyroid nodules are graded according to their ultrasound imaging description, including whether the nodule’s aspect ratio exceeds 1, whether the boundary is clear, whether there is abundant blood flow signal, and whether there is calcification. If a thyroid nodule is accompanied by calcification, most patients are graded at grade 4 or higher, which means that there is some possibility of malignancy. If a thyroid nodule with calcification is less than 1 cm in diameter, it can be closely monitored and followed up regularly or promptly by cytocentesis to exclude the possibility of thyroid cancer. If the diameter is more than 1.5 cm and the thyroid nodule is accompanied by calcification, surgical excision is recommended and intraoperative freezing is recommended to exclude the possibility of thyroid cancer.