Gout is a group of diseases caused by disorders of purine metabolism and is characterized clinically by hyperuricemia and the resulting recurrent episodes of gouty acute arthritis, gouty stone deposits, chronic gouty stone arthritis and joint deformities. Gout often involves the kidneys causing acute uric acid nephropathy, uric acid interstitial nephritis and uric acid kidney stones. The quality of life is seriously affected. Gout is based on hyperuricemia, the serum urate concentration increases with age, and there are gender differences, in childhood there is no difference between men and women, after sexual maturity men are higher than women, and after menopause women are close to each other, so men can develop hyperuricemia after developmental age, while women tend to occur after menopause, many patients with hyperuricemia can be asymptomatic for life, called asymptomatic hyperuricemia. Only when arthritis occurs is it called gout. The higher and longer the serum urate concentration, the greater the chance of gout and urinary tract stones. Here we talk about the general knowledge of uric acid: 1. The source of uric acid: it is divided into exogenous and endogenous. Exogenous usually refers to nuclear protein-rich foods. The endogenous source is the metabolism of a variety of substances in the body, accounting for 80% of the total. Endogenous is more important than exogenous. 2. Excretion of uric acid: 1/3 of uric acid is excreted or degraded through the intestine, and 2/3 is excreted through urine. In primary gout, 80%-90% of uric acid excretion is decreased. What symptoms do you need to be alert to whether you are suffering from hyperuricemia or even gout? 1. Obesity with hypertension, type 2 diabetes, hyperlipidemia and other metabolic diseases. 2, joint redness, swelling and heat pain, often can be self-relieved, relief may appear flaking and itching. And can be repeated, mostly after alcohol consumption, high protein diet, foot sprain. 3. Subcutaneous nodules appear in the hands, feet, auricles and around joints or other parts of the body. The following are some possible misconceptions about gout: 1. Only middle-aged men can suffer from gout. 95% of gout patients are men, and the high incidence age group is about 40 years old. However, as the standard of living of our people has improved, the purine content in the diet has become higher and higher, and many young people do not pay attention to their diet and also suffer from gout. For women, because estrogen can promote the excretion of uric acid, women are much less likely to suffer from gout than men. However, after menopause, women’s blood uric acid concentration will increase due to the decrease of estrogen level in the body, so they should pay attention to the occurrence of hyperuricemia and gout. 2, high uric acid must get gout. If there is no deposition of uric acid crystals in various parts of the body, hyperuricemia will not cause gout, but the higher the blood urate concentration and the longer the hyperuricemia, the greater the chance of gout. In addition, there are individual gout patients whose uric acid test results are not high. 3, antibiotics can also be anti-gout. Antibiotics do not work on the metabolism of uric acid. Some people are relieved after taking antibiotics probably because the initial symptoms of gout can be “self-healing”. For the acute attack of gout, the main treatment is to use some non-antibiotic anti-inflammatory and analgesic drugs to relieve the patient’s severe pain and eliminate the non-infectious inflammation of the joints caused by uric acid crystals; then use some drugs that regulate uric acid metabolism to help restore the balance of uric acid metabolism in the body.