Patient: description of the condition (onset time, main symptoms, hospital, etc.): gallbladder stones, about 11 * 8 mm (July physical examination, the main symptoms of nausea and vomiting, occasional abdominal pain, in taking gold gallbladder tablets and other Chinese and Western medicines) in taking medication can not be bile to remove the stone? The Baidu encyclopedia says it is quite good, if the gallbladder is removed, is it harmful? Please ask for treatment options? Thank you! Yuan Zhou, Department of General Surgery, Shanghai Sixth People’s Hospital: Cholecystectomy is the gold standard for gallbladder stones combined with cholecystitis, which has been proven for more than 100 years. Gall bladder surgery has been proven to have many drawbacks before, and there is no evidence-based medical proof of its superiority over cholecystectomy. I wish you a speedy recovery! Patient: Dr. Yuan, thank you! I would like to know how effective is the new minimally invasive gallbladder preservation surgery and is it really prone to recurrence? If the gallbladder is removed, will there be any sequelae or other medical conditions? I look forward to hearing from you. Yuan Zhou, Department of General Surgery, Shanghai Sixth People’s Hospital: Thank you for your trust in me! Gallbladder preservation surgery was once proven to be ineffective, but recently, due to the emergence of new devices, minimally invasive gallbladder preservation has been reintroduced repeatedly, especially because many patients want to preserve their gallbladder. From a scientific point of view, there is no evidence-based medical proof that biliary stone extraction surgery is the first choice for gallbladder stones combined with cholecystitis; however, science is dialectical, and perhaps in the future it will be proven that biliary stone extraction surgery is the first choice for gallbladder stones combined with cholecystitis. To be honest, many regular tertiary hospitals do not carry out this program, and I am not really sure, but I am following it. So, recurrence is an issue after minimally invasive biliary preservation surgery, but there is also the issue of gallbladder carcinomatosis. I ran into an unexpected gallbladder cancer today in surgery. In my specialist clinic this afternoon, I had 3 laparoscopic cholecystectomy and 2 open cholecystectomy patients followed up and all recovered well after surgery except for one who complained of occasional increased stool frequency (1-2 days a week with 2-3 bowel movements, but formed). Cholecystectomy is a very common operation, carried out in level 2 hospitals and even level 1 hospitals, but cholecystectomy is actually a risky and difficult operation because of its many anatomical variants, and most patients have surgical complications due to long-term cholecystitis attacks resulting in unclear local anatomy of the gallbladder; including some postoperative gallbladder syndromes, which are also caused by the operator leaving too long gallbladder duct. Therefore, I believe that standardizing the gallbladder removal well can reduce its postoperative complications. Taking the above into account, I still recommend you to prefer laparoscopic cholecystectomy. I wish you a speedy recovery!