Blocked blood vessels refer to blocked arterial vessels. The blockage of arterial blood vessels can be treated with medication and surgery. Drug treatment includes antiplatelet therapy and vasodilator drug treatment. Surgical treatment includes stenting, surgical bypass surgery, and endovascular stripping treatment. Drug therapy includes antiplatelet therapy and vasodilator drugs. Commonly used antiplatelet therapy drugs include aspirin and clopidogrel. Concurrent lipid-regulating therapy and anticoagulation therapy are required. Lipid modifying drugs are commonly used, and anticoagulant drugs such as warfarin and rivaroxaban are commonly used. In case of myocardial infarction caused by blockage of the coronary arteries, pharmacological thrombolytic therapy can be performed within the time window. If thrombolysis is ineffective or the time window for thrombolysis has been exceeded, percutaneous coronary intervention with stenting can be considered to reopen the blood vessels and restore blood supply. Surgical bypass surgery can also be performed according to the patient’s condition. In case of acute cerebral infarction, within the time window of 3 hours, intravenous thrombolysis or interventional stent installation or interventional thrombus retrieval treatment can be performed to save the patient’s life and reduce complications; in case of lower limb vascular occlusion, surgical vascular dissection for thrombus retrieval, interventional thrombus aspiration or stent placement treatment can be performed. In case of severe sclerotic stenosis of the internal carotid artery, carotid endarterectomy can be used to remove the sclerotic plaque. The treatment of vascular blockage depends on the location and degree of blockage as well as the clinical symptoms of the patient. Mild cases can be treated with medication, while severe cases can be treated with surgery or intervention.