Rheumatic diseases, especially systemic lupus erythematosus and systemic vasculitis, often have renal involvement. The presence of hematuria and proteinuria is an important sign of renal involvement. Specialists often judge the effectiveness of treatment and adjust medication based on the increase or decrease of urine protein. Urine protein results in routine urine tests are more commonly used for diagnosis and follow-up of outpatients than 24-hour urine protein quantification because they are economical and convenient. It is important to collect urine test specimens correctly. 1, the time to collect urine: any time to discharge urine can be done for routine laboratory tests. General kidney disease patients in order to observe the results before and after the first urine is required to be sent for testing early in the morning. 2, the amount of urine sent for testing: generally 5 to 10ml, such as to measure the specific gravity of the urine can not be less than 50ml. 3, the retention of urine specimens should be taken from the middle urine: that is, a part of the urine is first discharged and discarded to flush out the bacteria left in the urethra and the front urethra, and then the middle urine will be retained for testing. Care should be taken not to bring non-urinary components into the urine: for example, female patients should not mix in leukorrhea and menstrual blood (menstrual period is not advocated for routine urine tests), male patients should not mix in prostate fluid, etc.