Early symptoms of rheumatoid immune system diseases are generally characterized by swelling of the joints, morning stiffness and fever. Different rheumatic immune system diseases such as ankylosing spondylitis, rheumatoid arthritis and systemic lupus erythematosus have different early symptoms. 1. Ankylosing spondylitis: due to the slow onset and insidious early symptoms are not obvious, some patients in the early stage of the disease may appear in the lumbosacral region of the dull pain, accompanied by morning stiffness, usually after the activities of the symptoms can be reduced. 2. Rheumatoid arthritis: early symptoms mainly manifested as inflammation of joints, generally acute attack, will lead to joints red, swollen, hot and painful, accompanied by generalized fever symptoms, sometimes subcutaneous nodules. 3. Systemic lupus erythematosus (SLE): early on, symmetrical butterfly-shaped erythema may appear on the face, and patients may also have recurrent mouth ulcers, hand and foot rashes, and some patients with lupus erythematosus may have proteinuria and recurrent fever in the early stage. Rheumatic immune system diseases may also have some other symptoms in the early stage, if you feel unwell, you should go to the hospital in time, and take relevant examinations to confirm the diagnosis and targeted treatment.