1, mental stress stress, anxiety, depression is a high risk factor for premature ovarian failure. Some women, especially urban white-collar workers, are in a fast-paced, high-stress environment for a long time, resulting in dysfunction of the central nervous system and the hypothalamus-pituitary-ovarian axis, leading to abnormal secretion of follicle stimulating hormone and luteinizing hormone, ovulation dysfunction and amenorrhea, leading to ovarian dysfunction and reduced hormone levels. Coping strategies: get rid of stress and anxiety at the right time, de-stress yourself, release bad emotions and keep your mood relaxed. 2. Gonadal infections Pelvic infections may be an important cause of premature ovarian failure. Infectious factors associated with P O F include viral infections, bacterial infections, and atopic infections. The invasion of viruses, bacteria, and Mycobacterium tuberculosis into the ovaries leads to post-inflammatory fibrosis of the ovaries and a decrease in the number of follicles, which can develop into premature ovarian failure. It has been confirmed that women who have suffered from viral mumps at an early age are more prone to premature ovarian failure, which is strongly related to viral invasion of ovarian cells and tissues, resulting in decreased ovarian function and atrophy of reproductive organs. Coping strategies: Pay attention to vaccination and reproductive health from early childhood. Insist on exercise to strengthen the immunity of the body. The prevention and treatment of septic, tuberculous and gonorrheal pelvic inflammatory disease is also very important. 3, drug effects mainly include emergency contraceptives, anti-tumor drugs, antidepressants, drugs for insomnia and tretinoin, etc.. These drugs can inhibit ovarian function for a long time, leading to dysfunction, abnormal secretion of sex hormones and ovulation, and eventually ovarian function decline. Response strategy: do not easily (long-term) take the emergency contraceptive pill, take the drug before reading the adverse effects of drugs, or under the guidance of a doctor regular use of drugs. 4, excessive weight loss Most women in the pursuit of “white thin beauty” will be through dieting, vegetarian and other unhealthy ways to lose weight. If blind dieting and long-term vegetarianism will lead to malnutrition and affect the function of the pituitary gland, resulting in insufficient gonadotropin secretion and atrophy of the ovaries with reduced function. Response strategy: balanced diet, balanced nutrition, choose a scientific and healthy way to lose weight. Eat more fresh vegetables and fruits can resist premature ovarian failure. 5, over-stimulation of the ovaries In recent years, due to the postponement of the childbearing age, some women are forced to use the choice of ovulation methods to increase the chances of pregnancy, but if over-stimulation of the ovaries, the ovaries are still very damaging, easily causing the decline of ovarian function. Coping strategies: Getting rid of the pressure and having children at the right age is the way to go. Infertility, it is recommended to go to a regular specialist hospital for treatment. 6, genetic and autoimmune diseases Premature ovarian failure may be related to the genetic factors of the patient’s chromosomal abnormalities. Premature ovarian function decline may also be related to the autoimmune system. Studies have found that some patients with premature ovarian failure often have a combination of autoimmune diseases such as Addison’s disease, hashimoto’s thyroiditis or rheumatoid disease. Strategies: If you suspect that a genetic or autoimmune disease is causing premature ovarian failure, you must go to a regular specialist hospital for early treatment to avoid missing the best treatment time. In addition, environmental pollution, staying up late, insomnia, smoking, alcohol consumption and multiple abortions are all risk factors for premature ovarian failure. In order to prevent POF, it is important to stay up less, not to diet, to exercise and lose weight, to exercise, to enhance physical fitness, to relax and to keep a happy mood. Also pay attention to diet, balanced diet and nutrition, choose soy products and other safe phytoestrogen supplementation dietary therapy. The actual fact is that you can find a lot of people who are not able to get a good deal on their own, but you can’t get a good deal on your own, so you can change your lifestyle and habits and start with the little things that you need to do to stay healthy and beautiful!