With the development of detection technology nowadays, more and more patients with thyroid nodules are found clinically, and many people are worried about this, fearing that it may be cancer or develop into cancer in the future. In fact, benign nodules account for the majority of thyroid nodules and malignant nodules only account for about 1%. The clinical manifestation of thyroid cancer varies greatly, and small cancers can be completely asymptomatic. Regular thyroid ultrasound examination is recommended, and close monitoring with regular review. Meanwhile, the following cases should be taken seriously: 1) family history, that is, parents, siblings, uncles, aunts have thyroid cancer; 2) history of radioactive diagnosis and treatment of head or neck; 3) irregular shape of thyroid nodules with rapid enlargement, that is, rapid enlargement within one month or several months; 4) enlarged lymph nodes in the neck with hard texture; 5) difficulty in swallowing, voice 6. “Cold nodules” on nuclear imaging of the thyroid gland; 7. Single nodules have a higher chance of malignancy than multiple nodules, and young men should be more alert to the recent appearance of a single nodule; 8. High TSH.