Anti-androgen therapy 1. Androgen receptor antagonists 1.1 Spironolactone is a safe treatment for female acne. 1.2 Cyproterone: Daing-35, a compound containing cyproterone, is an effective treatment for mild to moderate female acne, especially for female patients with contraceptive needs. 2. Adrenal-derived androgen blockers Glucocorticoids for the treatment of coalescent acne, the inflammatory phase of cystic acne and burgeoning acne. 3. Ovarian-derived androgen blocking agents 3.1 Buserelin, nafarin and leuprolide are effective for female acne, but have significant side effects and are rarely used. 3.2 Oral contraceptives: Daing-35. 4. Enzyme inhibitors: Finasteride.