Cervical cancer is the most common gynecologic malignancy. Since cervical cancer has a long precancerous stage, cervical cytology allows for early diagnosis and early treatment of cervical cancer [1]. With the development of technology, an improved cytology production technique, liquid-based thin-layer cytology (TCT or LCT) production technique, has emerged in recent years. Liquid-based thin-layer cytology is a major innovation in filming technology, in which the impurities on the smear are removed through technical processing, and the smear is made directly into a clearly observed thin-layer smear, DNA stained, and diagnosed by a fully automated cellular DNA ploidy analysis system, making it easier for the reader to observe and its diagnostic accuracy higher than the traditional method. The results of liquid-based thin-layer cytology in 7800 patients with cervical lesions in our gynecology department from January 2005 to January 2007 are analyzed and summarized.
1. Data and methods
1.1 General information
From January 2005 to January 2007, 7,800 patients were screened in our gynecology outpatient clinic for universal screening of women between the ages of 20 and 70 who were married or had a history of sexual intercourse.
1.2 Methods
1.2.1 Suitable screening population
All women who are sexually active should undergo regular cervical exfoliation cytology testing, and particular attention should be paid to the following conditions:
① Sexual disorders, frequent sexual intercourse and STD patients;
②Patients who had sexual intercourse before the age of 18 or had multiple births after marriage;
③Patients with inflammation and erosion of the cervix;
④Vaginal bleeding after sexual intercourse, vaginal discharge after menopause, especially bloody discharge;
(⑤ Those with high risk of smoking and long-term use of contraceptive pills are required to be examined.
1.2.2 Precautions
①Cervical brush is not recommended for women in early pregnancy and menstruating women;
②Vaginal douching and medication are prohibited within three days of the test;
③No examination should be done before menstruation after abortion;
④Disposable brushes should be used when collecting cervical exfoliated cell specimens;
⑤Only one vial of cell preservation solution should be opened at a time; gloves should be worn and changed frequently when handling brushes and vials;
⑥Only one sample can be dispensed at a time, and only one vial can be opened;
(7) If there is active bleeding after sampling, apply pressure to stop the bleeding.
1.2.3 Specific operations
The brush is inserted completely into the vagina so that the shorter external bristles are in full contact with the external part of the cervical os, and then turned 4-5 times in one direction to collect the cells inside and outside the cervical os.
1.2.4 Reporting
The TBS reporting system and cooperation with Wuhan Landing Tumor Early Diagnosis Detection Center were used to provide timely consultation for suspicious cases to ensure the scientific and accurate diagnosis.
2.Results
ASC is a diagnostic term proposed in the TBS classification of cervical cytology, including atypical squamous epithelial cells without clear diagnostic significance and atypical squamous epithelial cells without excluding highly squamous intraepithelial lesions.ASC is not an exclusionary diagnosis, it may be a benign reactive change, or may hide squamous intraepithelial lesions, or a stage manifestation in the process of cervical lesion development [2]. It has been reported that 15% to 50% of biopsies performed on ASC are CIN, 5% to 10% are moderate to severe CIN, and some are even invasive carcinoma [3].
3. Discussion
Based on the above clinical results we believe that extensive early cervical cancer screening among women is necessary and meaningful, according to cervical precancerous lesions (CIN) i.e. from CINI grade, CIN grade II, CIN grade III, CC (cervical invasive carcinoma) often takes ten or fifteen years, so this suggests that our doctors have enough time and through the available scientific means to detect early Therefore, this suggests that we doctors have enough time and through the available scientific means to detect patients with cervical precancerous lesions at an early stage, to achieve early detection and early treatment. Thus, it is expected to completely eliminate cervical cancer and reduce the incidence of cervical cancer.
This technology is worth promoting and has far-reaching significance. Therefore, cervical pre-cancer screening should be widely carried out in our region for the benefit of women in our region, and to provide first-hand materials for the World Health Organization (WHO) to investigate the incidence of cervical cancer in China for statistical record retrieval. This method is easy to operate, easy to master, no trauma and side effects for patients, low cost of examination, easy to accept by patients, high and accurate diagnosis rate, and is a new technology worth promoting and applying.