There are many types of serious mental illnesses, which include anxiety disorders, depression, mania, and schizophrenia. The occurrence, development and aggravation of these disorders are closely related to seasonal changes. For example, as soon as the spring, Xiaoli’s schizophrenia symptoms will be aggravated, sensitive and suspicious, irritable, often occurring cups, smashing bowls, hitting people and other abnormal behaviors; and into the summer, these symptoms are much better; the Spring Festival has just passed, Xiaomei began to often insomnia, depression, do not want to go to work. This is a depressive state, need timely treatment. There is a folk saying that “cauliflower yellow, the obsessed son is busy”. That is to say, in the spring when rapeseed flowers bloom, the incidence and relapse rate of mental illness has entered an explosive stage, that is, spring is significantly higher than other seasons. Domestic survey shows that spring is the high incidence of schizophrenia, mania, depression, and its incidence rate is significantly higher than that of summer, fall and winter. Foreign research also found that anxiety, obsessive-compulsive, depression, suicide, schizophrenia and other diseases, its incidence rate also exists in the spring high, low summer characteristics. Why the onset of mental illness is associated with seasonal changes is unclear. Community and family guardians are aware of the need to improve control of people with mental illness in the spring to prevent accidents or injurious events. Patient visits are also often overcrowded during this season. For patients with severe mental illness, many family members would like to eliminate persistent mental symptoms through minimally invasive surgery so that they can return to the society as soon as possible. But which season is better for minimally invasive surgery? Some people believe that surgery is best when the disease is most severe, so that the doctor can observe the severity of the disease; some people want to operate in the spring, but the patient does not come to the clinic, and with the relief of the disease in the summer, the family hesitates; some people believe that winter is better, and is not prone to postoperative infection. The timing of the operation, the family has a lot to say. Functional neurologists believe that mental illness is characterized by recurrent episodes and constant aggravation, and even if there is seasonal relief, it is temporary. The best time for surgical treatment is when the patient’s symptoms are stabilized – that is, the summer and fall seasons, when the patient’s physical condition is good and his compliance is good, which is the best time for treatment. Surgical treatment is not based on the onset of symptoms at the time of hospitalization, but rather on a comprehensive analysis of all symptoms since the onset of the disease and the establishment of a correspondence with the nucleus pulposus of the nerves, followed by the formulation of a surgical plan, which results in a stable and long-lasting efficacy. As for surgical infection, the incidence is extremely low. Studies have shown that there is no correlation between the occurrence of infection and seasonal changes. Instead, there is a correlation between timeliness of treatment and efficacy. Surgery is not as effective as early treatment for patients with mental illness who are already in decline. In conclusion, experts remind that for severe mental illness, the best time for surgical treatment is in the summer and fall, and that symptom evaluation, preoperative examination and efficacy evaluation of the whole course of the disease are also important.