1.Significant loss of appetite: abdominal stuffiness and distension, indigestion, sometimes nausea and vomiting. 2. Liver pain: There may be persistent or intermittent pain in the liver area, sometimes aggravated by changes in position. It may radiate to the back or right shoulder. Severe abdominal pain and peritoneal irritation may occur suddenly in advanced liver cancer, which may be caused by necrosis of cancer nodes or bleeding into the abdominal cavity. At this time, patients often go to the emergency room with the manifestation of acute abdomen. 3. Systemic failure: severe weakness, emaciation, progressive anemia and edema. 4.Jaundice, ascites and itchy skin: are common symptoms of liver cancer. About 1/3 of the cases have jaundice during the course of development. The reason for jaundice is that the cancer invades the main bile ducts in the liver and the metastatic cancer in the hilar lymph nodes compresses the extrahepatic bile duct. Ascites is often caused by the patient’s pre-existing cirrhosis, the invasion of cancer tissue into the veins and the formation of cancer thrombi, and the compression of the portal vein by cancer nodes. Ascites often accumulates very quickly and can be straw-yellow or blood-colored. Itchy skin is a common symptom of liver disease and liver cancer patients. 5.Hemorrhage phenomenon: often manifested as nosebleeding and subcutaneous bleeding, mostly due to liver tissue destruction and liver failure. Portal hypertension can cause rupture and bleeding of esophageal and fundic varices. When cancer tissue invades the bile ducts in the hepatic hilum, it can cause biliary bleeding. 6.hepatomegaly, splenomegaly and fever: 90% of hepatocellular carcinoma have hepatomegaly. The enlarged liver is often hard, indicating irregularity, and the edges may have nodules of different sizes. Giant hepatocellular carcinoma can sometimes deform the liver so that it is not easily distinguishable on palpation. Splenomegaly mostly occurs in patients with hepatocellular carcinoma combined with cirrhosis. Metastatic splenic cancer is rare. Fever is quite common in patients with hepatocellular carcinoma, which may be due to ischemic necrosis of cancer tissue, absorption of necrosis products and concurrent infection. Therefore, self-examination is very important in general, and “early detection and early treatment” is the principle of liver cancer treatment, so we should pay attention to it in general. When you feel tired and cannot be relieved by lying down and resting, it is probably a sign of liver disease. If the cancerous tissue is bigger, there will be a dull feeling in the heart fossa or a dull pain in the upper right side of the abdomen. Even if it is less than painful, there will be a feeling of pressure and discomfort. Symptoms caused by stomach disorders, including loss of appetite, nausea, feeling of fullness after eating and drinking, and discomfort in the stomach, are also often present. If you lose weight, have fever of unknown origin, or develop jaundice, it is important to go to the hospital to receive confirmation of the diagnosis by AFP, ultrasound, CT, or X-ray liver angiography.