Patients with kidney disease often worry that the application of hormone therapy will become bloated and large-bellied. However, a series of side effects brought by hormone therapy, such as infection, ulcer, osteoporosis, hypertension, femoral necrosis, edema, increased blood sugar, full-moon face, big belly, tiger back and waist, make many people afraid to accept the treatment or give up halfway, making the disease aggravate or even develop into uremia. How to reduce the toxic side effects of drugs while achieving the purpose of treatment? Doctors believe that the onset and progression of immune nephritis is importantly related to local immune dysfunction within the kidney. In the treatment process, therapeutic drugs should be confined to the kidney as much as possible, trying to reduce the extra-renal distribution of drugs, so as to achieve the purpose of treatment of local kidney disease, but also to reduce the toxic side effects of the systemic distribution of drugs. Intrarenal capsule injection drug therapy is a local treatment method, after the drug enters the kidney capsule, the kidney fat capsule can be used as a drug storage site, and the drug enters the kidney tissue through diffusion, so that the kidney can maintain a high local drug concentration continuously, with fast onset of action and long maintenance time, and the amount of drug distributed in the plasma and other organs is reduced, so that toxic side effects and comorbidities are significantly reduced. Through renal capsule therapy, the dose of drug administration can be reduced and the duration of drug action can be prolonged, which can guarantee the effective treatment of kidney diseases with drugs and at the same time achieve non-invasive purpose, especially for patients who are not suitable for oral hormones, such as obesity, diabetes, ulcer disease, tuberculosis, hepatitis, hypertension, hyperlipidemia, etc. Clinical treatment of kidney disease by renal capsule drug injection has improved the kidney function of patients and reduced proteinuria, and no side effects or adverse reactions have been found.