Rheumatic diseases are autoimmune diseases that affect all systems of the body and belong to the category of difficult diseases, and the involvement of the eyes, nose and throat is one of their clinical manifestations; these diseases belong to the category of non-infectious non-neoplastic inflammatory diseases, and their pathogenesis is similar to rheumatic diseases. The prognosis of untreated patients with these diseases is very poor, such as deafness, blindness, mute, and death, especially when the eye or otorhinolaryngology is the first symptom. The results of the second census in China in 2006 showed that 14.8% of patients were blind due to glaucoma, cataract, uveitis, keratoconus and refractive error; 24.1% were deaf due to otitis media, drugs, systemic diseases and old age; 1.5% were mute due to hearing impairment, mental retardation and cerebral infarction, and many of them had unknown causes. Based on the pathogenesis of rheumatic immune diseases, it is reasonable to speculate that the cause of many people with disabilities is related to rheumatic diseases involving all organs of the five senses. Therefore, the ability to achieve early recognition, proper diagnosis and appropriate treatment is one of the key factors in the prognosis of such diseases. The diagnosis and treatment of such patients is an important element and highlight of the joint collaboration between the two key departments of ophthalmology and otorhinolaryngology and rheumatology of our hospital. A variety of rheumatic diseases can involve the eye and otorhinolaryngology; various parts of the eye and otorhinolaryngology can also be affected by rheumatic diseases, many of which are already known to the medical staff, but many more need to be further explored. For example, rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, leukoarthrosis, dry syndrome, vasculitis, Wegener’s granulomatosis, recurrent polychondritis, etc. All parts of the eye can be affected by rheumatic diseases and lead to conjunctivitis, keratitis, scleritis, uveitis, retinal vasculitis, optic neuritis and orbital diseases such as lacrimal gland enlargement, ocular muscle thickening, proptosis and ocular muscle paralysis. However, based on the complexity of medicine, it is necessary to distinguish other causes of ocular diseases such as infections such as tuberculosis and tumors such as lymphoma, in addition to rheumatic diseases. Various rheumatic diseases as well as inflammatory lesions of the eye, ear, nose and throat associated with rheumatic diseases require glucocorticoid therapy and, if necessary, combined immunosuppressive therapy. Therefore, the understanding of glucocorticoids and their rational application are essential knowledge for physicians in various fields. Glucocorticosteroids have been widely used in various fields of medicine. However, since the response to glucocorticoid therapy varies from one individual to another and from one disease to another, the philosophy and approach to the use of glucocorticoids varies greatly from one department to another and from one physician to another. These differences are reflected in the indications for the use of glucocorticoids, the dosage and dose adjustment, and the philosophy and measures for monitoring and preventing side effects. As with other drugs, inappropriate use of hormones can lead to serious adverse reactions, both on the part of the health care provider and the patient. Therefore, it is necessary to strengthen the publicity and education on the rational application of glucocorticoids in different diseases. In order to better grasp the skills of safe and effective use of hormones, the Rheumatology and Immunology Department of our hospital and more than 30 experts from our ophthalmology, otorhinolaryngology and neurosurgery departments gathered in December 2013 to have an extensive exchange on the issues of common concern about the rational application of hormones. At the meeting, Director Wang Zhengang from the Department of Rheumatology (hormone treatment of rheumatism with five senses involvement), Director Wang Chengshuo from the Department of Rhinology (hormone treatment of allergic rhinitis), Director Liu Bo from the Department of Otology (hormone treatment of immune hearing loss), Director Xu Wen from the Department of Laryngology (hormone treatment of laryngeal edema), and Director Peng Xiaoyan from the Department of Ophthalmology, represented by Cao Xusheng (hormone treatment of uveitis), respectively, explained and exchanged their views on the current situation and questions about the application of hormones in their departments. At the same time, they also made extensive communication and exchanges on the basic pharmacological characteristics of hormones and the action characteristics of various hormones, the mastering of indications, the selection of dose and usage, the prevention of side effects and the patient’s disease education and communication. We all agreed that the key points for the safe use of hormones are: mastering the indications for hormone use, choosing reasonable dosage and dose, appropriate course of treatment and timely dose adjustment according to the condition, paying attention to the monitoring and prevention of hormone side effects, and choosing appropriate combination drugs as appropriate. At the same time, medical practitioners were reminded to avoid the problems that both doctors and patients may have, such as not daring to use hormones when they should, blind use, lack of informed information and lack of medication monitoring. We all agreed that hormones are a drug that we both love and hate when we do not understand the characteristics and usage of hormones properly; once we understand the key points of hormone usage, we can avoid or minimize the side effects of hormones while making them perform their powerful therapeutic effects.