Three types of drugs are commonly used in the treatment of acute attacks of gout: non-steroidal anti-inflammatory analgesics, colchicine and glucocorticoids. The specific choice of drugs should be based on the patient’s age, condition and physical status. During the acute attack of gout, if there are no obvious contraindications it is currently recommended that NSAIDs should be administered as early as possible (generally within 24 hours), such as etoricoxib, diclofenac sodium, celecoxib, and loxoprofen sodium, but attention needs to be paid to the cardiovascular and gastrointestinal adverse effects of the drugs. Colchicine is a traditional drug for the treatment of acute gout attacks, but it is now less used because of its more adverse effects. Therefore, colchicine is currently used only for patients in the acute phase of gout who have contraindications to the use of non-steroidal anti-inflammatory analgesics. If the patient’s condition is severe, the effect of conventional drug treatment is not good, or there are contraindications to the use of non-steroidal anti-inflammatory analgesics and colchicine, short-term use of glucocorticoids can be considered to control symptoms, using small and medium doses, oral, intramuscular or intravenous injection can be used, but the symptoms are easy to “rebound” after stopping the drug. Some patients with advanced disease, the disease is stubborn and not easy to control can try anti-interleukin-1, anti-tumor necrosis factor and other biological agents. Therefore, the choice of medication for acute gout attacks depends on the specific situation of the patient, who should seek medical attention in a timely manner and be treated with additional medication as early as possible and in sufficient quantity under the guidance of a doctor, in order to quickly relieve the attack and develop a long-term control treatment plan.