The important feature that distinguishes TCM from Western medicine is the “holistic concept”, which comes from ancient Chinese philosophical thought and is based on a macroscopic and discursive model of medical activity. It is a unified analysis and understanding of “heaven, earth, and man”, a comprehensive cognition of human life phenomena and related matters, and a comprehensive grasp of the biological and social nature of man. It emphasizes the harmony and unity of the social background, human environment, state of existence, spirituality and quality of human life, and studies the physiology and pathology of human beings and the human body and the development of diseases from a philosophical point of view. The human mind and body are inseparable contradictory unities that are mutually antagonistic, interdependent and mutually influential. For example, there is a neurological system of its own in the inter-intestinal muscular plexus, which secretes neurotransmitters that also exist in the cerebral cortex-neurological system. This neurotransmitter is a peptide hormone, so it is also called “brain and intestinal peptide”. It has the dual identity of neurotransmitter and endocrine hormone, and it also takes on the role of immunity in human body. This huge neuroendocrine immune network system in human body is called “brain-gut axis”. The brain-gut coordination regulates the proper functioning of the human neuropsycho-intestinal tract. If one side is malfunctioning, it will lead to abnormal function of the other side. For example, strong life and work stress can affect a person’s mental state, and this bad emotional experience can affect a person’s gastrointestinal tract through the action of brain-gut axis and brain-gut peptides, causing some gastrointestinal diseases, such as functional dyspepsia, irritable bowel syndrome, functional constipation, functional diarrhea, and gas-swallowing disorder. These gastrointestinal disorders are typical psychosomatic disorders. Long-term gastrointestinal disorders cause somatic discomfort and can also lead to abnormalities in a person’s mental state. For example, in some chronic gastrointestinal diseases, such as functional gastrointestinal diseases, peptic ulcer, gastroesophageal reflux disease, most patients have more or less anxiety or depression in their psychological state. This is also a concrete testimony of the theory of “liver wood over earth” and “earth congestion and wood depression” in Chinese medicine in clinical practice. I have a patient with chronic ulcerative colitis, whose condition has been recurrent for more than 10 years. When he was referred to me, he had diarrhea with pus and blood, 5-6 times a day, accompanied by shortness of breath and abdominal pain before the stool, etc. After nearly 2 months of dialectical treatment, the patient improved significantly, with a yellow formed stool once a day, no pus and blood mucus, no shortness of breath and abdominal pain, and normal stool routine. However, 2 weeks later, I was surprised by the patient’s condition. Her condition not only worsened, with more than 10 stools per day, diarrhea with mucus and pus and blood, urgency, but also fever, high blood count, a full field of red and white blood cells in the stool routine, increased sedimentation, and mild anemia. I asked him about the reasons for the worsening of his condition, from diet, emotions, work and living conditions to the presence of infections and other triggers, but he denied all of them. I was at a loss for words, and I was unable to control the progression of the disease with pure Chinese medicine. Finally, I had to add the combination of 5-aminosalicylic acid and hormone treatment to gradually control the disease. Later, during a casual conversation with a close friend, I learned that the patient’s condition had taken a turn for the worse when she retired from work and found a new job out of boredom, and this new challenge was too much for her to handle. It finally dawned on me that the change in this person’s condition was triggered by emotional disorders and overwork. From this example, I learned that a doctor should not only analyze the changes in a patient’s condition from a biological perspective, but also recognize the development of his or her disease from a socio-psychological perspective in all aspects. There are things that patients are not aware of or are not willing to admit. This requires doctors to do a little social investigation, not only to pay attention to the patient’s body, but also to his or her social background, family situation, work environment, quality of life, psychological state, etc. In other words, to use the Chinese medicine term “TCM” to describe the development of the disease, we need to analyze the patient’s condition. In other words, the “holistic concept” of TCM is used to explore the patient’s pathophysiological phenomena in a holistic manner. At the same time, the doctor’s treatment goal for the patient should not be limited to the relief of symptoms and the improvement of laboratory data, but more importantly, to improve the quality of life. In my opinion, a person can eat, drink, sleep, urinate, defecate and sweat normally, which are the “three supplements” and “three diarrhea” of human physiology and are the basic guarantee of human life; while a happy psychological state is an important basis for improving the quality of survival. Therefore, a good doctor is not only a complete medical worker, but also half a social worker and half a psychological worker. The doctor’s work should be people-centered, work in a more humane way, grasp the physiological-psychological state of the patient as a whole, adjust the balance between the patient’s organism and the outside world, and achieve the harmony between man and nature and society. Nowadays, the medical model has changed from a purely biomedical model to a bio-social-psychological medical model. We have a long way to go, and only by focusing on life from the holistic concept of TCM can we achieve the real sense of medical paradigm change, so as to achieve the harmony and unity within the human body and with society and nature.