When fever occurs after HPV vaccination, it is generally considered to be caused by the body’s immune system reaction after vaccination, but it may also be caused by other bacterial or viral infections after vaccination, and should be treated accordingly. 1. Immune reaction: The inactivated vaccine enters the body to induce an immune response, which in turn causes the body to produce the corresponding antibodies, and fever may occur. Usually it appears within 24 hours after vaccination, most patients show low fever, generally not exceeding 38.5°C. Physical cooling can be used, such as warm water baths or topical antipyretic patches, which can generally be relieved by itself in 1-2 days, and if the body temperature exceeds 38.5°C, antipyretic and analgesic drugs can be used to reduce the temperature, such as ibuprofen and acetaminophen. Due to unclean diet and inattention to clean care of the vaccination site, it may lead to bacterial and viral infections, causing fever in the body, and recurrent fever may occur. It is recommended to go to the hospital for blood tests and take oral anti-inflammatory and anti-bacterial drugs or anti-viral drugs as prescribed by the doctor, and it is also recommended to drink more water and exercise properly to enhance resistance.