The diagnosis of endocarditis needs to be made from symptomatic presentation and ancillary investigations.
Clinically, patients present with varying degrees of fever with irregular and prolonged fever pattern, along with chronic fatigue, night sweats, loss of appetite, weight loss, joint pain and pale skin; the presence of murmurs and louder cardiac manifestations; or the presence of abdominal pain, haematuria, etc., combined with blood culture findings of bacteria and cardiac ultrasound findings of abnormal valves with superfluous organisms, are generally diagnostic.