Cardioid, the drug name is also known as Prenalol, is a beta-blocker. It can treat arrhythmia, angina pectoris and hypertension, and is an old drug that has been used in clinical practice for more than twenty years. By a chance, French doctors discovered another brand new use of the drug, namely the treatment of infantile hemangioma, and showed good results. The first case of hemangioma in a child with severe nasal capillary hemangioma leading to obstructive, hypertrophic cardiomyopathy was treated with ponerol by coincidence, and the authors logically used the beta receptor blocker (beta receptor blockader), a common hypotensive drug used in cardiology. The authors logically used propranolol, a beta receptor blocker commonly used in cardiology to lower blood pressure (2 mg/kg?d). The ingenious (one might say lucky) thing was that the hemangioma became progressively smaller during the course of the treatment and continued to improve even after the hormone treatment was stopped, and eventually the hemangioma almost disappeared completely. This happened again in another case. The authors found these 2 cases and, with the consent of the parents, they administered ponerol to 9 other children with facial hemangioma, all of whom saw a lightening of the color of the hemangioma within 24 h. None of the 11 children had any serious adverse effects, but some had low blood pressure. A search of the literature provided corroboration in exactly 1 paper regarding its mechanism, probably the ability of β-blockers to induce apoptosis in vascular endothelial cells, and other possible mechanisms such as causing a decrease in VEGF and bFGF gene expression and vasoconstrictive effects.