Embolic nephritis is one of the renal manifestations of renal damage in infective endocarditis, including cardiovascular interventional consultations and cardiac or non-cardiac procedures, intracardiac pressure monitoring intubation, atrioventricular shunts, high-energy nutrition, biopsies, pacemakers, arteriovenous intubation, catheters, tracheal intubation (especially in patients with burns, with reduced resistance). The bacteria that cause infective endocarditis or their products act as antigens and produce corresponding antibodies, both of which form a circulating immune complex. The site of deposition of the immune complex in the glomerulus is related to the type of bacteria and the period of infection, but depends mainly on the size and solubility of the antigen-antibody complex. Extra-epirenal manifestations of renal damage in infective endocarditis: often irregular fever of varying degrees, body temperature 37.5-39°C, flaccid type, higher in the afternoon and evening, with chills and night sweats, along with nonspecific symptoms such as general malaise, weakness, loss of appetite and weight loss, patients often complain of headache, chest and back and muscle and joint pain, and variable cardiac murmurs on physical examination, which may be pre-existing pathologic murmurs The patient may have augmented or new pathologic murmurs. About 70% of patients have embolism, which may be manifested by petechiae on the lid conjunctiva, oral mucosa and skin, lobar hemorrhage under the finger or toenail, retinal Roth spots, Osler’s nodes and Janeway damage. Most patients have progressive anemia, splenomegaly, elevated blood leukocytes, increased sedimentation, and 75% to 90% positive blood cultures for bacteremia. The common clinical manifestations of acute infective endocarditis are: acute septic infection, recent surgery, trauma, puerperal fever or history of instrumental examination, rapid onset, mainly septic signs such as chills, hyperthermia, sweating, weakness, skin and mucosal hemorrhage, shock, vascular embolism and migrating abscess, and most of the original infectious lesions can be found.