How long it takes for HPV18 infection to clear up on its own in women depends on the duration of the infection, the load and the individual patient. The problem should be analyzed on a case-by-case basis, and no generalizations should be made. In most cases, HPV infection in women is a transient infection and the risk of cervical intraepithelial lesions is high with HPV18 infection, but if the load is low, the infection is short-lived and the patient is immune, the infection may spontaneously turn negative within 3-6 months. Approximately 80% of patients with high-risk HPV infection will be negative after about 8-12 months, and only a minority of women have persistent infection. However, if HPV infection persists for 10-15 years, the patient is prone to cervical lesions or even cervical cancer. Therefore, once a female patient is found to be at high risk of HPV infection, it is recommended to visit the gynecology department of a regular hospital in a timely manner. Firstly, colposcopy should be performed to rule out the occurrence of cervical intraepithelial neoplasia by pathological examination. If no lesion occurs, regular rechecking of HPV is recommended.