Glioma is the most common primary intracranial tumor in neurosurgery, accounting for 40-60% of intracranial tumors. The clinical symptoms of glioma are mainly divided into two main categories, one is high cranial pressure symptoms caused by tumor occupancy, i.e., due to the increase of intracranial pressure, which causes the patient’s headache, nausea, vomiting, and fundus edema and other symptoms. Among them, vomiting is not different from ordinary nausea and vomiting caused by eating, but a kind of projectile vomiting. The other type of symptoms are different changes caused by the tumor invading different functional areas. For example, glioma occurring in the frontal lobe will be manifested as mental behavioral changes, especially in the frontal lobe glioma of the elderly, which will lead to slow reflection, abnormal mental behavior, and even urination and defecation; the temporal lobe is in charge of the human body’s language and auditory centers, and if glioma occurs here, it may lead to sensory aphasia, that is, the patient can’t understand what other people are saying, and the patient can’t answer what he is saying; glioma occurring in the occipital lobe will lead to patients’ If the glioma occurs in the occipital lobe, it will cause the patient to have visual field defects; and if the glioma occurs in the motor function area of the brain, such as the precentral gyrus and the postcentral gyrus, the patient will have sensory or motor disorders, that is, hemiplegia or hemiparesis, and so on. Moreover, the vast majority of patients with gliomas have epileptic seizures as their main manifestation, and the location of the tumor is different, so is the site of the seizure. Do all gliomas need to be surgically removed? Is it possible to operate on gliomas in important functional areas? Gliomas are mainly surgical at present, but it does not mean that all patients can be operated. Whether it is possible to operate or not is related to many factors, such as age, location of the tumor, and whether the tumor is confined or not. For some patients with advanced age and poor physical condition, surgery is not suitable; if the tumor is located in important brain function areas, such as diffuse infiltrative growth in the brainstem, surgery is also not suitable; if the tumor is huge and diffuse growth, or even involves both cerebral hemispheres, which is difficult to be separated from the surrounding normal brain tissues, it can’t be surgically resected either. In addition, surgery should be able to relieve clinical symptoms. If the surgery fails to alleviate the headache, nausea, vomiting, or even improve the motor sensory function of the patient, then the surgery is of little significance. In addition, whether surgery is suitable or not also needs to consider the survival period of the patient. If the grade of the tumor is particularly high, and the expected survival period is less than three months, then it makes little sense to do surgery. There are also a few patients with simple epileptic seizures as the main symptom, which are considered to be low-grade gliomas, and there is no obvious change of the lesion in the follow-up observation, so close observation can be considered, and surgery can be avoided for the time being, because there are a few patients with quiescent tumors in the clinical observation, and the tumors have survived for 10 years or even more than 20 years without any interventions. Once the tumor progresses, surgery will be performed. Of course, there is some controversy about whether or not to operate on these patients. What symptoms can surgery relieve? Surgical removal of the tumor can alleviate the tumor-occupying effects, such as relieving symptoms like headache and vomiting. For functional gliomas where the tumor is more confined, surgery can also help to restore brain function in the compressed area. Some patients may have dysfunction such as aphasia or even hemiparesis prior to surgery, which can also be improved through surgery. Surgery can also control the symptoms of epilepsy, which are primarily characterized by seizures.